| Pair Name | Perillyl alcohol, Temozolomide | ||
| Phytochemical Name | Perillyl alcohol (PubChem CID: 10819 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Perillyl alcohol, Temozolomide | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| In Vitro Model | HL-60 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_0002 |
| U-937 | Adult acute monocytic leukemia | Homo sapiens (Human) | CVCL_0007 | |
| In Vivo Model | For U937 cell implantation, used NSG-SGM3 mice and intravenously (via tail vein) injected 5×10⁴ tumor cells in a volume of 200 µL 0.9% NaCl. For 4D9 and 6D10 cells, used NOD-SCID mice. | |||
| Result | Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia | |||
| No. | Title | Href |
|---|---|---|
| 1 | Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia. Cancers (Basel). 2021 Jul 6;13(14):3385. doi: 10.3390/cancers13143385. | Click |
